Cervical Dystonia: From Pathophysiology to Pharmacotherapy

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Cervical Dystonia: From Pathophysiology to Pharmacotherapy

BACKGROUND Dystonia is a chronic disorder characterised by an aberration in the control of movement. Sustained co-contraction of opposing agonist and antagonist muscles can cause repetitive and twisting movements, or abnormal postures. Cervical dystonia (CD), often referred to as spasmodic torticollis, is a type of focal dystonia involving the muscles of the neck and sometimes the shoulders. ...

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[Pathophysiology of dystonia].

Dystonia is a diverse movement disorder characterized by involuntary muscle co-contraction of the agonist and antagonist, which may cause twisting and repetitive movements or abnormal posture. Dystonia is the least understood movement disorder associated with the basal ganglia dysfunction. While dysfunction of cortico-striatal-thalamo-cortical motor circuits is likely to play a fundamental role...

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Cervical dystonia responsive to levodopa

276 CMYK Figure 2b: Magnetic resonance venography (Sagittal) images show non-visualization of the superior sagittal sinus and only partial visualization of the right transverse and sigmoid sinuses. Figure 2a: Magnetic resonance venography (Coronal) images show non-visualization of the superior sagittal sinus and only partial visualization of the right transverse and sigmoid sinuses. Letter to E...

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Cervical Dystonia

There is now strong evidence demonstrating that bilateral globus pallidus internus (GPi) stimulation improves motor function and disability in patients with severe primary generalised, segmental or cervical dystonia. The improvement is gradual, typically occurring over a period of about six months, with pain and then phasic components dissipating before the tonic elements of dystonia. Controlle...

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The pathophysiology of primary dystonia.

Co-contraction and overflow of EMG activity of inappropriate muscles are typical features of all dystonic movements whether voluntary or involuntary. Voluntary movements are slow and more variable than normal, and there is particular difficulty switching between component movements of a complex task. Reduced spinal cord and brainstem inhibition is common to many reflex studies (long-latency ref...

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ژورنال

عنوان ژورنال: Behavioural Neurology

سال: 2013

ISSN: 0953-4180,1875-8584

DOI: 10.1155/2013/817426